LY-404039
A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively; displays >100-fold selectivity over other ionotropic glutamate receptors, glutamate transporters; suppresses electrically evoked excitatory activity in the striatum, and serotonin-induced l-glutamate release in the prefrontal cortex; reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats; oral bioavailable. Schizophrenia Phase 1 Clinical.
Product Specifications
CAS Number
635318-11-5
Product Name Alternative
LY 2140023 | LY404039
Purity
>98% (HPLC)
Solubility
DMSO:1 mg/mL; H2O:< 1 mg/mL
Smiles
O=S1 (C[C@] (C (O) =O) (N) [C@@H]2[C@@H] (C (O) =O) [C@@H]21) =O
Molecular Formula
C7H9NO6S
Molecular Weight
235.2145
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid, 4-amino-, 2,2-dioxide, (1R,4S,5S,6S) -
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