Tozasertib
Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively; also inhibits the imatinib-resistant ABL (T315I) kinase with Kd of 5 nM, displays >100-fold selectivity for the Aurora-A kinase over 55 other kinases with the only exception FLT-3 (Ki=30 nM) ; blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor types; causes profound inhibition of tumor growth in a variety of in vivo xenograft models.Blood Cancer Discontinued.
Product Specifications
CAS Number
639089-54-6
Product Name Alternative
MK-0457 | VX-680 | MK0457 | VX680 | VX 680 | MK 0457
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (C1CC1) NC2=CC=C (SC3=NC (NC4=CC (C) =NN4) =CC (N5CCN (C) CC5) =N3) C=C2
Molecular Formula
C23H28N8OS
Molecular Weight
464.5864
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclopropanecarboxamide, N-[4-[[4- (4-methyl-1-piperazinyl) -6-[ (5-methyl-1H-pyrazol-3-yl) amino]-2-pyrimidinyl]thio]phenyl]-
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