L-Phenylalanine

L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM Target: Calcium Channel L-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. (In Vitro) :DAHP synthetase (DS) and chorismate mutase/prephenate dehydratase (CM/PD) are key enzymes in the L-Phenylalanine biosynthesis pathway. DS is sensitive to feedback inhibition by tyrosine, and CM/PD is subject to feedback inhibition by L-Phenylalanine. L-Phenylalanine attenuates non-NMDA receptor function in cultured neurons with an IC50 of 980 μM. (In Vivo) :The effects of L-Phenylalanine on NMDA-activated currents (INMDA) are studied in cultured hippocampal neurons from newborn rats using the patch-clamp technique. L-Phenylalanine specifically and reversibly attenuates INMDA in a concentration-dependent manner (IC50 of 1.71 mM) . L-Phenylalanine inhibits specifically NMDAR current in hippocampal neurons by competing for the glycine-binding site.