Phenoxybenzamine hydrochloride
Phenoxybenzamine HCl is a non-specific, irreversible alpha antagonist with long duration of action. (In Vitro) :Phenoxybenzamine hydrochloride (0-100 μM; 96 h) markedly inhibits U251 and U87MG cells proliferation.Phenoxybenzamine hydrochloride (10 μM; 24 h or 72 h) inhibits migration and invasion of U251 and U87MG cells.Phenoxybenzamine hydrochloride (10 μM; 12 h) activates LINGO-1 and inhibits the TrkB-Akt pathway.Phenoxybenzamine (0.1 μM-1 mM; 0-16 h) prevents hippocampal cell death after oxygen glucose deprivation. (In Vivo) :Phenoxybenzamine hydrochloride (20 nM; s.c.; 2-day interval for 26 days) shows anti-tumorigenic effect in mice.Phenoxybenzamine (1.0 mg/kg; i.v.; daily for 30 days) is neuroprotective in a rat model of severe traumatic brain injury.
Product Specifications
CAS Number
63-92-3
Product Name Alternative
Dibenzyline? | NSC 37448
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 68 mg/mL (199.82 mM) ; Water: 17 mg/mL (49.95 mM) ; DMSO: 68 mg/mL (199.82 mM)
Smiles
Cl.CC (COC1=CC=CC=C1) N (CCCl) CC1=CC=CC=C1
Molecular Formula
C18H23Cl2NO
Molecular Weight
340.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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