AS-605240
AS-605240 (AS605240) is a potent, selective, ATP-competitive, orally active PI3Kγ inhibitor with IC50 of 8 nM; displays 30-fold selectivity for PI3Kδ、β, 7.5-fold selectivity over PI3Kα; inhibits C5a-mediated PKB phosphorylation in RAW264 mouse macrophages (IC50=90 nM) ; reduces neutrophil chemotaxis in vivo and suppresses joint inflammation and damage in mouse models of RA.
Product Specifications
CAS Number
648450-29-7
Product Name Alternative
AS605240 | AS 605240
Purity
>98% (HPLC)
Solubility
DMSO: 5.8 mg/mL (Need warming)
Smiles
O=C (NC/1=O) SC1=C\C2=CC=C3N=CC=NC3=C2
Molecular Formula
C12H7N3O2S
Molecular Weight
257.2679
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Thiazolidinedione, 5- (6-quinoxalinylmethylene) -
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