Phentolamine mesilate
Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist. (In Vitro) :Phentolamine (0.1-1 μM) inhibits the response to Clonidine in rat ileum, with the pA2 and pKB of 7.92 and 8.07, respectively.Phentolamine (10-70 μg/mL; 48 h) inhibits proliferation of HDMECs and HBMECs in a dose-dependent manner, with IC50s of 50 μg/mL and 30 μg/mL without toxicity, respectively.Phentolamine (10-20 or 20-40 μg/mL; 12-48 h) signi cantly delays scratch wound closure of HBMECs and HDMECs in a dose-dependent manner.Phentolamine (30 or 50 μg/mL; 4-12 h) inhibits tube formation of HBMECs and HDMECs. (In Vivo) :Phentolamine (1 mg/kg; i.v.) produces hypotension and tachycardia in rats.
Product Specifications
CAS Number
65-28-1
Product Name Alternative
Regitine | Vasomax
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 76 mg/mL (201.34 mM) ; Water: 76 mg/mL (201.34 mM) ; DMSO: 76 mg/mL (201.34 mM)
Smiles
CS (O) (=O) =O.CC1=CC=C (C=C1) N (CC1=NCCN1) C1=CC (O) =CC=C1
Molecular Formula
C17H19N3O·CH4O3S
Molecular Weight
377.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (((4,5-dihydro-1H-imidazol-2-yl) methyl) (p-tolyl) amino) phenol methanesulfonate
Available Sizes
Frequently Asked Questions
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