SU11274
SU11274 (PKI-SU11274) is a potent, selective, ATP-competitive c-Met kinase inhibitor with IC50 of 20 nM, >50-fold selectivity over Bcr-Abl, JAK2, PDGFβR; induces G (1) cell cycle arrest and apoptosis with increased Annexin V staining and caspase 3 activity, specifically regulates cell growth in TPR-MET-transformed BaF3 cells with IC50 of <3 uM, differentially affects the kinase activity and subsequent signaling of various mutant forms of Met (M1268T and H1112Y) .
Product Specifications
CAS Number
658084-23-2
Product Name Alternative
SU 11274 | PKI-SU11274 | SU-11274
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=S (C1=CC2=C (NC (/C2=C\C3=C (C) C (C (N4CCN (C) CC4) =O) =C (C) N3) =O) C=C1) (N (C5=CC=CC (Cl) =C5) C) =O
Molecular Formula
C28H30ClN5O4S
Molecular Weight
568.0869
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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