SU11274

SU11274 (PKI-SU11274) is a potent, selective, ATP-competitive c-Met kinase inhibitor with IC50 of 20 nM, >50-fold selectivity over Bcr-Abl, JAK2, PDGFβR; induces G (1) cell cycle arrest and apoptosis with increased Annexin V staining and caspase 3 activity, specifically regulates cell growth in TPR-MET-transformed BaF3 cells with IC50 of <3 uM, differentially affects the kinase activity and subsequent signaling of various mutant forms of Met (M1268T and H1112Y) .

Product Specifications

CAS Number

658084-23-2

Product Name Alternative

SU 11274 | PKI-SU11274 | SU-11274

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

O=S (C1=CC2=C (NC (/C2=C\C3=C (C) C (C (N4CCN (C) CC4) =O) =C (C) N3) =O) C=C1) (N (C5=CC=CC (Cl) =C5) C) =O

Molecular Formula

C28H30ClN5O4S

Molecular Weight

568.0869

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1H-Indole-5-sulfonamide, N- (3-chlorophenyl) -3-[[3,5-dimethyl-4-[ (4-methyl-1-piperazinyl) carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z) -