Nimodipine
Nimodipine (Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+, Beclin-1 and autophagy. (In Vitro) :Nimodipine (1.5~150 μg/ml; 15 minutes; B16a and W256 cells) results in a dose-dependent inhibition of B16a and W256 tumor-cell-induced platelet aggregation. Nimodipine is also inhibitory in a homologous system. (In Vivo) :Nimodipine (0.2 μg/μl, intrathecal administration) prevents subarachnoid hemorrhage-associated cerebral vasospasm by prophylactic continuous intrathecal administration.Nimodipine (0.1~80 mg/kg; p.o.) results in a significant dose-dependent inhibition of spontaneous metastasis.
Product Specifications
CAS Number
66085-59-4
Product Name Alternative
Admon | BAY-e 9736 | Periplum
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 84 mg/mL (200.74 mM) ; DMSO: 84 mg/mL (200.74 mM)
Smiles
CC1=C (C (OCCOC) =O) C (C2=CC ([N+] ([O-]) =O) =CC=C2) C (C (OC (C) C) =O) =C (C) N1
Molecular Formula
C21H26N2O7
Molecular Weight
418.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-isopropyl 5- (2-methoxyethyl) 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate
Available Sizes
Frequently Asked Questions
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