Pergolide mesylate salt
PERGOLIDE MESYLATE is a long-acting dopamine agonist which has been used to treat parkinson disease and hyperprolactinemiabut withdrawn from some markets due to potential for heart valve diseases. (In Vitro) :Pergolide (10 nM-50 μM) treatment dose-dependently inhibits H2O2-induced cell death in SH-SY5Y neuroblastoma cells. Pergolide protects SH-SY5Y neuroblastoma cells from cell death specifically induced by H2O2, acting in very low concentrations (nanomolar range) and in very early stages of the neurotoxic intracellular process. (In Vivo) :Pergolide (0.3 mg/kg; intraperitoneal injection; daily; 11 days) treatment reduces the number of working/reference memory errors a 6-OHDA-induced rat model of Parkinson's disease. Pergolide facilitates spatial memory and improves brain oxidative balance .
Product Specifications
CAS Number
66104-23-2
Product Name Alternative
LY127809 | NSC 319773
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO 10 mg/mL; Water 82 mg/mL
Smiles
[H][C@@]1 (N (CCC) C[C@H] (CSC) C[C@@]12[H]) CC3=CNC4=C3C2=CC=C4.CS (=O) (O) =O
Molecular Formula
C20H30N2O3S2
Molecular Weight
410.59
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
8-beta- ((Methylthio) methyl) -6-propylergoline methanesulfonate
Available Sizes
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