TGX-221
A potent, selective PI3K p110β inhibitor with IC50 of 8.5 nM; weakly inhibits p110δ (IC50=211 nM), and no activity against p110α (IC50>1 uM) ; inhibits platelet-ECC interaction, platelet aggregation and platelet-granulocyte binding; shows anti-thrombotic effectt devoid of other cardiovascular actions in rats.
Product Specifications
CAS Number
663619-89-4
Product Name Alternative
TGX221 | TGX 221
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1C=C (N2CCOCC2) N=C3N1C=C (C) C=C3C (NC4=CC=CC=C4) C
Molecular Formula
C21H24N4O2
Molecular Weight
364.4409
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4H-Pyrido[1,2-a]pyrimidin-4-one, 7-methyl-2- (4-morpholinyl) -9-[1- (phenylamino) ethyl]-
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