Amantadine hydrochloride

Amantadine Hydrochloride is an antiviral and an antiparkinsonian drug. (In Vitro) :Amantadine hydrochloride (0-500 μM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 μM.Amantadine hydrochloride (0-100 μg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC 7721 cells.Amantadine hydrochloride (0-75 μg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces apoptosis.Amantadine hydrochloride (0-75 μg/mL, 48 h) reduces the levels of the cell cycle related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels. (In Vivo) :Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment.