O-phenanthroline
A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM; shows no activity for other DUBs (USP1/USP2/USP4/USP5/USP7/USP8/USP20/UCH37, IC50>50 uM) ; blocks cellular proteasome function, induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib, activates caspase cascade and endoplasmic stress response signaling; reduces progression of tumor growth and prolongs survival in mice MM xenograft model. (In Vitro) :o-Phenanthroline (1,10-Phenanthroline, 1mM) inhibits autolysis of sea cucumber body wall.
Product Specifications
CAS Number
66-71-7
Product Name Alternative
1,10-phenanthroline | Ortho-phenanthroline | OPA
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (554.91 mM)
Smiles
C1=CC2=C (C3=C (C=CC=N3) C=C2) N=C1
Molecular Formula
C12H8N2
Molecular Weight
180.21
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4,5-Diazaphenanthrene
Available Sizes
Frequently Asked Questions
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