BIO
A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM; also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM) ; maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog; promotes proliferation in mammalian cardiomyocytes.
Product Specifications
CAS Number
667463-62-9
Product Name Alternative
6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 23 mg/mL
Smiles
O=C (/C1=C2NC3=C (C\2=N/O) C=CC=C3) NC4=C1C=CC (Br) =C4
Molecular Formula
C16H10BrN3O2
Molecular Weight
356.1735
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Indol-2-one, 6-bromo-3-[ (3E) -1,3-dihydro-3- (hydroxyimino) -2H-indol-2-ylidene]-1,3-dihydro-, (3Z) -
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