LDN-57444
A reversible, competitive, active site-directed Uch-L1 inhibitor with IC50 of 0.88 uM; shows weak inhibition on Uch-L3 (IC50> 20 uM) ; causes cell death through the apoptosis pathway by decreasing the activity of ubiquitin proteasome system and increasing the levels of highly ubiquitinated proteins, both of which can activate UPR.
Product Specifications
CAS Number
668467-91-2
Product Name Alternative
Ubiquitin C-terminal Hydrolase L1 Inhibitor | UCH-L1 Inhibitor
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C1N (CC2=CC (Cl) =CC=C2Cl) C3=C (C=C (Cl) C=C3) /C1=N/OC (C) =O
Molecular Formula
C17H11Cl3N2O3
Molecular Weight
397.6398
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Indole-2,3-dione, 5-chloro-1-[ (2,5-dichlorophenyl) methyl]-, 3- (O-acetyloxime)
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