Nutlin-3a
The active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay; blocks the binding of Mdm2 to key signaling molecules such as p53 and p73α and can result in activation of cell death signaling pathways.
Product Specifications
CAS Number
675576-98-4
Product Name Alternative
Nutlin 3a
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) OC1=C (C=CC (=C1) OC) C2=N[C@H] ([C@H] (N2C (=O) N3CCNC (=O) C3) C4=CC=C (C=C4) Cl) C5=CC=C (C=C5) Cl
Molecular Formula
C30H30Cl2N4O4
Molecular Weight
581.4896
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Piperazinone, 4-[[ (4S,5R) -4,5-bis (4-chlorophenyl) -4,5-dihydro-2-[4-methoxy-2- (1-methylethoxy) phenyl]-1H-imidazol-1-yl]carbonyl]-
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