GW 4869
A cell-permeable, symmetrical dihydroimidazolo-amide compound that acts as a potent, specific, non-competitive inhibitor of N-SMase (neutral sphingomyelinase) [IC50 = ~ 1 μM, rat brain; Km for sphingomyelin ~13 μM]. Does not inhibit human A-SMase (acid sphingomyelinase) even at 150 μM. Weakly inhibits the activities of bovine protein phosphatase 2A and mammalian lyso-PAF PLC, while no inhibition is observed for bacterial phosphatidylcholine-specific PLC. Reported to offer complete protection against TNF-α or diamine-induced cell death in MCF7 breast Y cells at 20 μM. Does not modify the intracellular glutathione levels or interfere with TNF-α or diamine-mediated signaling effects.
Product Specifications
CAS Number
6823-69-4
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
C1NC (=NC1) C2=CC=C (C=C2) NC (=O) /C=C/C3=CC=C (C=C3) /C=C/C (=O) NC4=CC=C (C=C4) C5=NCCN5.Cl.Cl
Molecular Formula
C30H30Cl2N6O2
Molecular Weight
577.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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