SRJ-23
A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation; significantly suppresses K-Ras GTP loading, whereas H-Ras and N-Ras GTP loading are much less sensitive; reduceds K-RasG12V GTP, phosphorylated ERK (ppERK) levels in K-RasG12V-transformed cells; induces G1 arrest and apoptosis in MCF-7 and HCT-116 cells, respectively.
Product Specifications
CAS Number
865285-29-6
Product Name Alternative
SRJ23 | SRJ 23
Purity
>98% (HPLC)
Solubility
DMSO: Soluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NC1=NN=NN1CCC) C2=CC=CC (Cl) =C2
Molecular Formula
C15H9ClFN3O2
Molecular Weight
317.704
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Chloro-N-[5- (4-fluorophenyl) -1,3,4-oxadiazol-2-yl]-benzamide
Available Sizes
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