Umeclidinium bromide
Umeclidinium bromide (GSK 573719A) is potent, long-acting, inhaled antagonist of mAChRs with Ki of 0.05-0.16 nM for human M1-M5 mAChRs; demonstrates picomolar potency (-log pA2=23.9 pM) in an acetylcholine-mediated Ca (2+) mobilization assay in CHO cells transfected M3 mAChRs; dose dependently blocks Ach-induced bronchoconstriction with long duration of action in mice model of pulmonary diseases.COPD Approved.
Product Specifications
CAS Number
869113-09-7
Product Name Alternative
GSK573719A | GSK-573719A | GSK 573719A
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 34 mg/mL
Smiles
OC (C1=CC=CC=C1) (C2=CC=CC=C2) C34CC[N+] (CC4) (CCOCC5=CC=CC=C5) CC3.[Br-]
Molecular Formula
C29H34BrNO2
Molecular Weight
508.4897
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Azoniabicyclo[2.2.2]octane, 4- (hydroxydiphenylmethyl) -1-[2- (phenylmethoxy) ethyl]-, bromide (1:1)
Available Sizes
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