TW-37
TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities; potently inhibits cell growth in PC-3 prostate cancer cells with an IC (50) value of 200 nM and effectively induces apoptosis in a dose-dependent manner; shows antiangiogenic effect against endothelial cells (IC50=1.8 uM) with no cytotoxic effects for fibroblasts, induces endothelial cell apoptosis by mitochondrial depolarization and activation of caspase-9 and caspase-3, decreases the density of functional human microvessels in mouse model of human angiogenesis.
Product Specifications
CAS Number
877877-35-5
Product Name Alternative
TW 37 | TW37
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 42 mg/mL
Smiles
O=C (NC1=CC=C (S (=O) (C2=CC=CC=C2C (C) (C) C) =O) C=C1) C3=CC (CC4=CC=CC=C4C (C) C) =C (O) C (O) =C3O
Molecular Formula
C33H35NO6S
Molecular Weight
573.6991
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[4-[[2- (1,1-dimethylethyl) phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2- (1-methylethyl) phenyl]methyl]-
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Multiplex Assay Kit for Citrate Synthase (CS), etc. by FLIA (Flow Luminescence Immunoassay)
Lentiviral human LARGE2 shRNA (UAS) - Lentiviral human LARGE2 shRNA (UAS, iRFP) plasmid
