TW-37
TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities; potently inhibits cell growth in PC-3 prostate cancer cells with an IC (50) value of 200 nM and effectively induces apoptosis in a dose-dependent manner; shows antiangiogenic effect against endothelial cells (IC50=1.8 uM) with no cytotoxic effects for fibroblasts, induces endothelial cell apoptosis by mitochondrial depolarization and activation of caspase-9 and caspase-3, decreases the density of functional human microvessels in mouse model of human angiogenesis.
Product Specifications
CAS Number
877877-35-5
Product Name Alternative
TW 37 | TW37
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 42 mg/mL
Smiles
O=C (NC1=CC=C (S (=O) (C2=CC=CC=C2C (C) (C) C) =O) C=C1) C3=CC (CC4=CC=CC=C4C (C) C) =C (O) C (O) =C3O
Molecular Formula
C33H35NO6S
Molecular Weight
573.6991
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[4-[[2- (1,1-dimethylethyl) phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2- (1-methylethyl) phenyl]methyl]-
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