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BI-78D3

A small molecule JIP1 mimic that functions as substrate competitive inhibitor of JNK with IC50 of 500 nM; targets the JNK-JIP interaction site and dose-dependently inhibits the phosphorylation of JNK substrates both in vitro and in cell; blocks JNK dependent Con A-induced liver damage, restores insulin sensitivity in mouse models of type 2 diabetes.

Product Specifications

CAS Number

883065-90-5

Product Name Alternative

BI 78D3 | BI78D3

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 31 mg/mL

Smiles

O=C1NN=C (SC2=NC=C ([N+] ([O-]) =O) S2) N1C3=CC=C (OCCO4) C4=C3

Molecular Formula

C13H9N5O5S2

Molecular Weight

379.37106

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

3H-1,2,4-Triazol-3-one, 4- (2,3-dihydro-1,4-benzodioxin-6-yl) -2,4-dihydro-5-[ (5-nitro-2-thiazolyl) thio]-

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