Disodium clodronate tetrahydrate

Clodronic acid (INN) orclodronate disodium (USAN) is a first generation (non-nitrogenous) bisphosphonate. It is an anti-osteoporotic drug approved for the prevention and treatment of osteoporosis in post-menopausal women and men to reduce vertebral fractures, hyperparathyroidism, hypercalcemia in malignancy, multiple myeloma and fracture related pain because of its potent anti-inflammatory and analgesic effects shown as a reduction in inflammatory markers like IL-1β, IL-6, and TNF-alfa. (In Vitro) :Clodronate disodium tetrahydrate, a first-generation bisphosphonate, significantly attenuates neuropathic and inflammatory pain unrelated to bone abnormalities via inhibition of VNUT, a key molecule for the initiation of purinergic chemical transmission .Clodronate disodium tetrahydrate is an allosteric modulator of VNUT Cl- dependence .Clodronate disodium tetrahydrate acts as antiresorptive in osteoporosis. (In Vivo) :Clodronate disodium tetrahydrate (10 mg/kg; i.v.) attenuates inflammatory pain via VNUT inhibition.Clodronate disodium tetrahydrate attenuates inflammation via VNUT inhibition .