Fosinopril sodium
Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure. (In Vitro) :Fosinopril (0, 1, 10, 33, 100μM; 30 min) partially inhibits the cosedimentation of liposomes and recombinant LPLA2.Fosinopril (250 nM) shows no inhibition of the soluble esterase activity of LPLA2.Fosinopril (0.372, 0.744, 1.116 μM) displays a non-competitive inhibition effect on ACE activity with a Ki value of 1.675 μM. (In Vivo) :Fosinopril (orally; 4.67 mg/kg; 4 weeks) downregulates the creatine kinase (CK) and lactate dehydrogenase (LDH) levels and against cardiac dysfunction and structural alteration.Fosinopril (orally; 4.67 mg/kg; 4 weeks) suppresses cleaved-caspase 3 expression and myocardial apoptosis in AMI rat model.
Product Specifications
CAS Number
88889-14-9
Product Name Alternative
SQ 28,555
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 4 mg/mL (6.83 mM) ; Water: 117 mg/mL (199.78 mM)
Smiles
CCC (=O) OC (C (C) C) OP (=O) (CCCCC1=CC=CC=C1) CC (=O) N2C[C@@H] (C[C@H]2C (=O) [O-]) C3CCCCC3.[Na+]
Molecular Formula
C30H45NO7P·Na
Molecular Weight
586.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sodium; (2S,4S) -4-cyclohexyl-1-[2-[ (2-methyl-1-propanoyloxypropoxy) - (4-phenylbutyl) phosphoryl]acetyl]pyrrolidine-2-carboxylate
Available Sizes
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