MK 8776
MK 8776 (SCH 900776) is a potent and functionally selective CHK1 inhibitor (IC50=3 nM) with minimal intrinsic antagonistic properties; also inhibits CDK2 with IC50 of 160 nM, weak activity for CHK2 and no significant inhibition of cytochrome P450 isoforms; induces dose-dependent suppression of CHK1 pS296 and concomitant accumulation of phospho-RPA signal in U2OS cells; interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in the A2780 xenograft model.Blood Cancer Phase 2 Discontinued.
Product Specifications
CAS Number
891494-63-6
Product Name Alternative
SCH 900776
Purity
>98% (HPLC)
Solubility
DMSO: 3 mg/mL (7.97 mM) ; Ethanol: <1 mg/mL; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
NC1=C (Br) C ([C@H]2CNCCC2) =NC3=C (C4=CN (C) N=C4) C=NN13
Molecular Formula
C15H18BrN7
Molecular Weight
376.25
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-bromo-3- (1-methyl-1H-pyrazol-4-yl) -5- (3R) -3-piperidinyl-pyrazolo[1,5-a]pyrimidin-7-amine
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