Dimethyloxaloylglycine
DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase. (In Vitro) :DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC. (In Vivo) :DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.
Product Specifications
CAS Number
89464-63-1
Product Name Alternative
DMOG
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
O=C (OC) CNC (C (OC) =O) =O
Molecular Formula
C6H9NO5
Molecular Weight
175.14
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (methoxyoxoacetyl) -glycine, methyl ester
Available Sizes
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