R788 free base
Fostamatinib (R788) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM; dose-dependently inhibits anti-IgE-mediated CHMC degranulation with an EC50 of 56 nM, inhibits all phosphorylation events downstream of Syk signaling; specifically inhibits FcγR signaling in human mast cells, macrophages, and neutrophils. R788 can inhibit local inflammatory injury mediated by immune complexes; reduces immune complex-mediated inflammation in arthritis models. Rheumatoid Arthritis Phase 3 Clinical.
Product Specifications
CAS Number
901119-35-5
Product Name Alternative
Fostamatinib | R788
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
COC1=CC (NC2=NC=C (F) C (NC3=NC4=C (OC (C) (C) C (=O) N4COP (O) (O) =O) C=C3) =N2) =CC (OC) =C1OC
Molecular Formula
C23H26FN6O9P
Molecular Weight
580.4595
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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