CH-0793076 (TFA)

CH-0793076 (TP3076) TFA, a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 TFA inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 TFA is efficacious against cells expressing BCRP (breast cancer resistance protein) [1].

Product Specifications

CAS Number

[2740278-76-4]

Product Name Alternative

TP3076 (TFA)

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ch-0793076-tfa.html

Purity

98.71

Solubility

DMSO : 30 mg/mL (ultrasonic)

Smiles

O=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N2CC(C3=N4)=C5N(CCCCC)C=NC6=C5C4=CC=C6)=O.O=C(O)C(F)(F)F

Molecular Formula

C28H27F3N4O6

Molecular Weight

572.53

References & Citations

[1]Endo M, et al. A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts. Cancer Chemother Pharmacol. 2010 Jan;65 (2) :363-71.