ICRT-3
ICRT-3 is a selective, cell-permeable β-catenin responsive transcription (CRT) inhibitor with IC50 of 8.2 nM; interferes with β-cat-TCF4 interaction via direct β-catenin (β-cat) binding, inhibits cellular expression of CRT target genes, including WISP1, AXN2, and CYCD1, in a dose-dependent manner (25-75 uM) ; selectively inhibits the proliferation of HCT116 (75 μM), HT29 (75 μM), and several primary human colon cancer cultures (6.25-100 μg/ml) .
Product Specifications
CAS Number
901751-47-1
Product Name Alternative
ICRT3
Purity
>98% (HPLC)
Solubility
DMSO: 150 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NCCC1=CC=CC=C1) CSCC2=C (C) OC (C3=CC=C (CC) C=C3) =N2
Molecular Formula
C23H26N2O2S
Molecular Weight
394.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-[[[2- (4-ethylphenyl) -5-methyl-4-oxazolyl]methyl]thio]-N- (2-phenylethyl) acetamide
Available Sizes
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