AZ960
A potent, selective JAK2 inhibitor with Ki of 0.45 nM, IC50 of <3 nM; displays 3-fold selectivity over JAK3 (IC50=9 nM) ; blocks STAT5 phosphorylation and potently inhibits cell proliferation (GI50=25 nM) in TEL-JAK2 driven Ba/F3 cells, blocks BCL-XL, PIM1 and PIM2 mRNA expression and induces apoptosis; also induces growth arrest and apoptosis in adult T-cell leukemia cells; also inhibits parasite Trypanosoma brucei ERK8 (Ki=1.25 uM) with antiparasitic activity (IC50=120nM) .Blood Cancer Preclinical.
Product Specifications
CAS Number
905586-69-8
Product Name Alternative
AZ-960 | AZ 960
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
N#CC1=C (N[C@H] (C2=CC=C (F) C=C2) C) N=C (NC3=NNC (C) =C3) C (F) =C1
Molecular Formula
C18H16F2N6
Molecular Weight
354.3566464
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-Pyridinecarbonitrile, 5-fluoro-2-[[ (1S) -1- (4-fluorophenyl) ethyl]amino]-6-[ (5-methyl-1H-pyrazol-3-yl) amino]-
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