SNX 2112
SNX 2112 (PF 04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β; shows weak affinity for Hsp90 family members Grp94 and Trap-1 (IC50=0.8-4.2 uM) ; has properties and potency, including degradation of HER2, mutant EGFR, and other client proteins, inhibition of ERK and Akt activation, and induction of a Rb-dependent G1 arrest with subsequent apoptosis; the orally bioavailbe prodrug SNX-5422, inhibits MM cell growth and prolongs survival in a xenograft murine model.
Product Specifications
CAS Number
908112-43-6
Product Name Alternative
PF 04928473
Purity
>98% (HPLC)
Solubility
DMSO: 86 mg/mL (185.2 mM) ; Ethanol: 1 mg/mL (2.15 mM) ; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (N) C1=CC=C (N2N=C (C (F) (F) F) C3=C2CC (C) (C) CC3=O) C=C1N[C@H]4CC[C@H] (O) CC4
Molecular Formula
C23H27F3N4O3
Molecular Weight
464.489
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (6,6-Dimethyl-4-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-indazol-1-yl) -2- (trans-4-hydroxy-cyclohexylamino) -benzamide
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