CGI-1746
CGI-1746 is a potent, highly selective, second-generation BTK inhibitor with IC50 of 1.9 nM, displays 1,000-fold selectivity over Tec and Src family kinases; displays no significant binding affinity for other 385 kinases; abolishes FcγRIII-induced TNFα, IL-1β and IL-6 production in macrophages, blocks B cell receptor-dependent B cell proliferation and in prophylactic regimens reduces autoantibody levels in collagen-induced arthritis; inhibits myeloma-like tumors both in vitro and in vivo.
Product Specifications
CAS Number
910232-84-7
Product Name Alternative
CGI1746 | CGI 1746
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=C (NC1=CC=CC (C (N=C2NC3=CC=C (C (N4CCOCC4) =O) C=C3) =CN (C) C2=O) =C1C) C5=CC=C (C (C) (C) C) C=C5
Molecular Formula
C34H37N5O4
Molecular Weight
579.6887
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[3-[4,5-dihydro-4-methyl-6-[[4- (4-morpholinylcarbonyl) phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4- (1,1-dimethylethyl) -
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