Terbinafine

A synthetic antifungal agent that inhibits the synthesis of ergosterol by inhibiting squalene epoxidase; used to treat ringworm, pityriasis versicolor, and fungal nail infections.Fungal Infection Approved (In Vitro) :Terbinafine has a primary fungicidal action in vitro against most fungal pathogens, including dermatophytes, and dimorphic and filamentous fungi. Terbinafine specifically inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation. The treated fungal cells rapidly accumulate tlic intermediate squalene and become deficient in the end-product of the pathway, ergosterol. (In Vivo) :Terbinafine is not only active after topical application but is very effective in experimental dermatophytoses following oral administration. In fungi infected guinea-pigs, the skin temperature dropps dramatically after the fourth treatment of terbinafine.