YHO-13177
YHO-13177 is a acrylonitrile derivative and active form of YHO-13351 that can specifically reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo; reverses BCRP-mediated acquired resistance to SN-38 in A549 cells without cytotoxicity, also shows no effect on P-glycoprotein-mediated paclitaxel resistance in MDR1-transduced human leukemia K562 cells and multidrug resistance-related protein 1-mediated doxorubicin resistance in MRP1-transfected human epidermoid cancer KB-3-1 cells.
Product Specifications
CAS Number
912287-56-0
Product Name Alternative
YHO13177
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
N#C/C (C1=CC=C (OC) C (OC) =C1) =C\C2=CC=C (N3CCC (O) CC3) S2
Molecular Formula
C20H22N2O3S
Molecular Weight
370.4653
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzeneacetonitrile, α-[[5- (4-hydroxy-1-piperidinyl) -2-thienyl]methylene]-3,4-dimethoxy-, (αZ) -
Available Sizes
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