Veliparib dihydrochloride
Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively; displays no activity against SIRT2 and selective biochemical profile in a panel of 74 receptor-binding assays; strongly potentiates temozolomide in the B16F10 s.c. murine melanoma model, also potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models. Breast Cancer Phase 3 Clinical.
Product Specifications
CAS Number
912445-05-7
Product Name Alternative
ABT-888 dihydrochloride | ABT888 dihydrochloride | ABT 888 dihydrochloride
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 3.2 mg/mL
Smiles
C[C@@]1 (CCCN1) C2=NC3=C (C=CC=C3N2) C (=O) N.Cl.Cl
Molecular Formula
C13H18Cl2N4O
Molecular Weight
317.2142
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Benzimidazole-7-carboxamide, 2-[ (2R) -2-methyl-2-pyrrolidinyl]-, hydrochloride (1:2)
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