Smoothened Agonist (SAG)
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM) ; potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM) .
Product Specifications
CAS Number
912545-86-9
Product Name Alternative
Smoothened Agonist
Field of Research
Stem Cell & Developmental Biology; Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 40 mg/mL warmed (75.97 mM) ; Water: 100 mg/mL (189.92 mM) ; DMSO: 71 mg/mL warmed (134.84 mM)
Smiles
CNC1CCC (CC1) N (CC1=CC=CC (=C1) C1=CC=NC=C1) C (=O) C1=C (Cl) C2=CC=CC=C2S1
Molecular Formula
C28H28ClN3OS
Molecular Weight
490.06
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
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