Opaganib
Opaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM; shows no activity against SphK-1 with IC50 of >100 uM; attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments; demonstrates antitumor activity in adenocarcinoma xenograft models.Blood Cancer Phase 2 Clinical.
Product Specifications
CAS Number
915385-81-8
Product Name Alternative
ABC294640 | ABC 294640 | ABC-294640
Purity
>98% (HPLC)
Solubility
DMSO: 71 mg/mL (186.4 mM) ; Ethanol: 27 mg/mL (70.9 mM) ; Water: <1 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C ([C@@]12C[C@]3 (C4=CC=C (Cl) C=C4) C[C@@] (C2) ([H]) C[C@] (C3) ([H]) C1) NCC5=CC=NC=C5
Molecular Formula
C23H25ClN2O
Molecular Weight
380.916
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (4-chlorophenyl) -adamantane-1-carboxylic acid (pyridin-4-ylmethyl) amide
Available Sizes
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