AS1517499
A novel potent STAT6 inhibitor with IC50 of 21 nM in STAT6-dependent promoter reporter assay; inhibits IL-4-induced Th2 differentiation of mouse spleen T cells with IC50 of 2.3 nM, without influencing Th1 differentiation induced by IL-12; completely inhibits both the antigen-induced up-regulation of RhoA and BSM hyperresponsiveness, significantly inhibits antigen-induced production of IL-13 in mice.
Product Specifications
CAS Number
919486-40-1
Product Name Alternative
AS-1517499 | AS 1517499
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 35 mg/mL
Smiles
C1ccc (cc1) CNc2c (cnc (n2) NCCc3ccc (c (c3) Cl) O) C (=O) N
Molecular Formula
C20H20ClN5O2
Molecular Weight
397.8581
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-Pyrimidinecarboxamide, 2-[[2- (3-chloro-4-hydroxyphenyl) ethyl]amino]-4-[ (phenylmethyl) amino]-
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