Daurisoline-d2
Product Specifications
UNSPSC Description
Daurisoline-d2 is the deuterium labeled Daurisoline (HY-N0221). Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer[1][2].
Target Antigen
Autophagy; Isotope-Labeled Compounds; Potassium Channel
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy;Membrane Transporter/Ion Channel;Others
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
OC1=C([2H])C2=C(C=C1OC)CCN(C)[C@@H]2CC3=CC([2H])=C(O)C(OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4)=C3
Molecular Weight
612.75
References & Citations
[1]Liu Q, et al. Effect of daurisoline on HERG channel electrophysiological function and protein expression. J Nat Prod. 2012 Sep 28;75(9):1539-45.|[2]Wu MY, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017 Sep 8;8(44):77673-77684.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Curated Selection
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