Glimepiride
Glimepiride is the first III generation sulphonyl urea it is a very potent sulphonyl urea with long duration of action. (In Vivo) :Glimepiride (Glimperide) is a new sulfonylurea. After oral administration of Hoe 490 to rabbits, blood glucose was lowered 3.5 times more than after glibenclamide (HB 419) and after intravenous administration, 2.5 times more. Glimepiride (Glimperide) decreased extracellular Aβ40 and Aβ42 levels. glimepiride may serve as a promising drug for the treatment of AD associated with diabetes. Glimepiride (Glimperide) was generally associated with lower risk of hypoglycemia and less weight gain compared to other sulfonylureas. Glimepiride (Glimperide) use may be safer in patients with cardiovascular disease because of its lack of detrimental effects on ischemic preconditioning.
Product Specifications
CAS Number
93479-97-1
Product Name Alternative
HOE 490
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 11 mg/mL (22.42 mM)
Smiles
CCC1=C (CN (C1=O) C (=O) NCCC2=CC=C (C=C2) S (=O) (=O) NC (=O) NC3CCC (CC3) C) C
Molecular Formula
C24H34N4O5S
Molecular Weight
490.62
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-ethyl-3-methyl-N-[2-[4-[ (4-methylcyclohexyl) carbamoylsulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide
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KIR2DL2, CT (KIR2DL2, CD158B1, NKAT6, Killer cell immunoglobulin-like receptor 2DL2, CD158 antigen-like family member B1, MHC class I NK cell receptor, Natural killer-associated transcript 6, p58 natural killer cell receptor clone CL-43, CD158b1) (MaxLigh
