TG-101348
TG-101348 (Fedratinib, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F; also inhibits FLT3 (IC50=15 nM) and RET (IC50=48 nM) kinases, weakly inhibits JAK3 (IC50=168 nM), >35-fold selectivity over JAK1/3 and Tyk2; shows therapeutic efficacy in a murine model of myeloproliferative disease induced by the JAK2V617F mutation; also potently inhibits BRD4 with Kd of 168 nM.Bone Cancer Phase 3 Clinical.
Product Specifications
CAS Number
936091-26-8
Product Name Alternative
Fedratinib | SAR 302503 | TG101348 | TG 101348
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 42 mg/mL
Smiles
O=S (C1=CC=CC (NC2=NC (NC3=CC=C (OCCN4CCCC4) C=C3) =NC=C2C) =C1) (NC (C) (C) C) =O
Molecular Formula
C27H36N6O3S
Molecular Weight
524.6782
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenesulfonamide, N- (1,1-dimethylethyl) -3-[[5-methyl-2-[[4-[2- (1-pyrrolidinyl) ethoxy]phenyl]amino]-4-pyrimidinyl]amino]-
Available Sizes
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