KU-0063794
A potent, specific, cell permeant inhibitor of mTOR with IC50 of 10 nM for both mTORC1 and mTORC2; displays no activity against 76 other protein kinases or seven lipid kinases, including class 1 PI3Ks (>1,000-fold) ; suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK, also inhibits phosphorylation of the T-loop Thr308 of Akt, induces complete dephosphorylation of 4E-BP1 in HEK-293 cells; suppresses cell growth and induces G1-cell cycle arrest in both wild-type and mLST8 deficient MEFs.
Product Specifications
CAS Number
938440-64-3
Product Name Alternative
KU 0063794 | KU0063794
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
OCC1=CC (C2=NC3=NC (N4C[C@@H] (C) O[C@@H] (C) C4) =NC (N5CCOCC5) =C3C=C2) =CC=C1OC
Molecular Formula
C25H31N5O4
Molecular Weight
465.5447
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzenemethanol, 5-[2-[ (2R,6S) -2,6-dimethyl-4-morpholinyl]-4- (4-morpholinyl) pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-, rel-
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