VTP-27999
A potent, highly selective renin inhibitor with IC50 of 0.47 nM; displays >1000-fold selectivity for renin over a panel of >150 receptors, ion channels, and enzymes, and has an IC50 value >30 uM against CYP3A4; demonstrates >15% oral bioavailability in three species, oral efficacy in a double transgenic rat model of hypertension, and good exposure in humans.Hypertension Phase 1 Clinical.
Product Specifications
CAS Number
942142-51-0
Product Name Alternative
VTP27999 | VTP 27999
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CNC (CC1CCCOC1) CNC (=O) N2CCCC (C2) C (C3=CC (=CC=C3) Cl) OCCNC (=O) OC
Molecular Formula
C26H41ClN4O5
Molecular Weight
525.0806
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Carbamic acid, N-[2-[ (R) - (3-chlorophenyl) [ (3R) -1-[[[ (2S) -2- (methylamino) -3-[ (3R) -tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]-, methyl ester
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