AZ304
AZ304 is a novel potent, dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF and wild type CRAF with IC50 of 79 nM, 38 nM and 68 nM, respectively; also potentlt inhibits p38 and CSF1R with IC50 of 6 and 35 nM, has no activity for MAP3K7, CSK, IGF1R, EGFR, FGFR, CDK2, CDK4, JAK2, SRC (IC50>5 uM) ; potently reduces p-ERK with mean EC50 of 65 nM in the V600E mutant BRAF containing melanoma cell line A375, EC50 of 60 nM in wild type BRAF melanoma cell line SK-MEL-31; inhibits cell proliferation in mutant BRAF, wt BRAF/RAS and mutant RAS with IC50 of 0.08-7.72 uM, 0.43-11.7 uM 0.9-16.66 uM, respectively; Cetuximab enhances the potency of AZ304 independently of BRAF mutational status in vivo.
Product Specifications
CAS Number
942507-42-8
Product Name Alternative
AZ 304 | AZ-304
Purity
>98% (HPLC)
Solubility
DMSO: 85 mg/mL; Ethanol: 4 mg/mL; Water: Insoluble (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NC1=CC=C (C) C (NC2=C3C=CC (OC) =CC3=NC=N2) =C1) C4=CC=CC (C (C) (C#N) C) =C4
Molecular Formula
C27H25N5O2
Molecular Weight
451.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3- (2-cyanopropan-2-yl) -N- (3- ((7-methoxyquinazolin-4-yl) amino) -4-methylphenyl) benzamide
Available Sizes
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