Butyl 4-aminobenzoate

Butamben is a long-duration local anesthetic used for the treatment of chronic pain. (In Vitro) :Butamben (500 μM) blocks 90% of the control barium current, and this level is reached within 4 min in PC12 cells.Butamben (100 μM; 2-10 min) increases the inactivation of the fast Na+ channels, but not of the slow Na+ channels. (In Vivo) :Butamben (0.5-50 mM; the distal portion of the tail was immersed for 2 min) has an S-shape dose-dependent analgesic activity in the radiant heat tail-flick assay of mice.