GSK-1070916
A potent, selective and ATP-competitive inhibitor of Aurora B and C with Ki of 0.38 nM and 1.5 nM, respectively; displays >250-fold selectivity over Aurora A; shows potent antiproliferative effect (EC50=7 nM) in A549 human lung cancer cells; causes inhibition of histone H3 phosphorylation at serine 10 in human colon cancer (Colo205) and tumor regression in human leukemia (HL-60) in mice.Ovarian Cancer Phase 2 Clinical.
Product Specifications
CAS Number
942918-07-2
Product Name Alternative
GSK1070916 | GSK 1070916
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 26.5 mg/mL
Smiles
O=C (NC1=CC=C (C2=NN (CC) C=C2C3=C4C (NC (C5=CC=CC (CN (C) C) =C5) =C4) =NC=C3) C=C1) N (C) C
Molecular Formula
C30H33N7O
Molecular Weight
507.6293
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Urea, N'-[4-[4-[2-[3-[ (dimethylamino) methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N, N-dimethyl-
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