JNJ-38877605
JNJ-38877605 is a potent, selective, ATP-competitive inhibitor of catalytic activity c-Met with IC50 of 4 nM; exhibits >600-fold selectivity (cFMS IC50=2.6 uM; the next potently inhibited kinase) against a panel of 250 diverse tyrosine and serine-threonine kinases; inhibits Met phosphorylation associated with dose-dependent tumor growth inhibition in tumor xenograft models; orally bioavailable.Solid Tumors Phase 1 Discontinued.
Product Specifications
CAS Number
943540-75-8
Product Name Alternative
JNJ38877605 | JNJ 38877605
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 30 mg/mL
Smiles
CN1N=C (C2=NN3C (C=C2) =NN=C3C (C4=CC=C5N=CC=CC5=C4) (F) F) C=C1
Molecular Formula
C19H13F2N7
Molecular Weight
377.3502
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 6-[difluoro[6- (1-methyl-1H-pyrazol-4-yl) -1,2,4-triazolo[4,3-b]pyridazin-3-yl]methyl]-
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