Peficitinib
Peficitinib (ASP-015K, JNJ-54781532) is a potent JAK inhibitor with IC50s of 3.9 and 0.7 nM for JAK1 and JAK3 respectively; inhibits IL-2-dependent T cell proliferation in vitro and STAT5 phosphorylation in vitro and ex vivo; dose-dependently suppresses bone destruction and paw swelling in an adjuvant-induced arthritis model in rats; orally bioactive.Rheumatoid Arthritis Phase 3 Clinical.
Product Specifications
CAS Number
944118-01-8
Product Name Alternative
ASP-015K | JNJ-54781532
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 60 mg/mL
Smiles
C1C2CC3CC (C2) (CC1C3NC4=C5C=CNC5=NC=C4C (=O) N) O
Molecular Formula
C18H22N4O2
Molecular Weight
326.3929
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrolo[2,3-b]pyridine-5-carboxamide, 4-[ (5-hydroxytricyclo[3.3.1.13,7]dec-2-yl) amino]-, stereoisomer
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