Remodelin
A potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules; significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells; does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.
Product Specifications
CAS Number
949912-58-7
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
C1CCC (=NNC2=NC (=CS2) C3=CC=C (C=C3) C#N) C1
Molecular Formula
C15H14N4S
Molecular Weight
282.3635
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzonitrile, 4-[2- (2-cyclopentylidenehydrazinyl) -4-thiazolyl]-
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