Liproxstatin-1
Liproxstatin-1 is a specific small molecule ferroptosis inhibitor (IC50=22 nM) via inactivation of the ferroptosis regulator Gpx4 (glutathione peroxidase 4), shows no activity on necroptosis; prevents BODIPY 581/591 C11 oxidation in Gpx4 / cells, does not interfere with other classical types of cell death, such as TNFα-induced apoptosis and H2O2-induced necrosis; suppresses ferroptosis in Gpx4 (-/-) mice, and in a pre-clinical model of ischaemia/reperfusion-induced hepatic damage.
Product Specifications
CAS Number
950455-15-9
Product Name Alternative
Liproxstatin 1
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
ClC1=CC (CNC (C23CCNCC2) =NC4=C (N3) C=CC=C4) =CC=C1
Molecular Formula
C19H21ClN4
Molecular Weight
340.8499
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Spiro[piperidine-4,2' (1'H) -quinoxalin]-3'-amine, N-[ (3-chlorophenyl) methyl]-
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